Current Issue : January-March Volume : 2014 Issue Number : 1 Articles : 4 Articles
In this review it is necessary to understand the capacities of the pharmaceutical industry to meet the new challenges arising from the TRIPS Agreement. In past, pharmaceutical industry did not face any rigours of strong patent systems. The new situation is going to be totally different. This article will give brief review on pharmaceutical market of India, Indonesia, Sri Lanka and a co-relation between the pharmaceutical policy and the patent laws has to be established to the maximum extent so that the industry is able to play its role adequately to facilitate easy access to medicines at competitive prices. Rising research and development (R&D) expenditures by pharmaceutical industries are, in part, a consequence of changing industry structure, notably the increase of the biotechnology sector....
In recent years, various newer drugs are discovered which are unstable in nature due to higher content of water in the molecules. Also most of the biotechnological & food products are having short storage period because of instability. Freeze drying is a most suitable but cost intensive method for improving the stability & long term storage by reducing the water content from labile products. Freeze drying principle mainly depends on sublimation process in which frozen ice is directly converts in to water vapors. Freeze drying also known as lyophilization. Generally freeze drying process applied in pharmaceutical, biological & food industries. This review focused on principle behind the process, steps involved of freeze drying & its application in industrial processes....
Liquisolid technique is a novel and promising approach to improve dissolution properties of water insoluble drugs. In this technique, liquid medications i.e. liquid drug, drug solution or suspension present in suitable nonvolatile solvent are converted into free-flowing and compressible powder by physical blending with a selected solid carrier and coating material. It has been theoretically believed that such systems exhibit enhanced release profiles due to the increased wetting properties and surface of drug available for dissolution. This technique is used to formulate water-insoluble drugs into rapid or sustained release solid dosage forms. This review shade light on the delivery of various water insoluble drugs by enhancing the solubility. The basic concept, mechanism of solubility enhancement, characterization and application of liquisolid compact....
The enhancement of oral bioavailability of poorly water soluble drugs is the biggest challenge in the new drug development in recent years. On the basis of recent findings, it is revealed that majority of approved new drugs were water insoluble. However, the release rate is increased by improvement of the solubility through various methods. Out of these methods solid dispersion is the excellent technique for the solubility enhancement and thereby enhances the oral bioavailability. Solid dispersion can be prepared by different methods like solvent evaporation, dropping solution, fusion (melt), hot melt extrusion, lyophilization, spray drying method and many others. The purpose of this review article is to describe the solid dispersion technique for the attainment of effective absorption and improved bioavailability. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier, molecular arrangement of drugs in solid dispersions are discussed in this article. This article also reviews various techniques for evaluation of solid dispersion and explains various applications of the solid dispersion in pharmaceuticals....
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